Science

Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo

1 month ago   |   By Harvard

Yingxia Liang, Frank Raven, Joseph F Ward, Sherri Zhen, Siyi Zhang, Haoqi Sun, Sean J Miller, Se Hoon Choi, Rudolph E Tanzi, and Can Zhang. 6/24/2020. “ Upregulation of Alzheimer's Disease Amyloid-β Protein Precursor in Astrocytes Both in vitro and in vivo .” Journal of Alzheimer's Disease. Publisher's Version Abstract Background:The amyloid cascade hypothesis of Alzheimer's disease posits that amyloid-β protein accumulation underlies the pathogenesis of the disease by leading to the formation of amyloid plaques, a pathologic hallmark of AD. Aβ is a proteolytic product of amyloid-β protein...
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