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Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma

1 month ago   |   By Harvard

Rui-Sheng Wang, Damien C Croteau-Chonka, Edwin K Silverman, J Loscalzo, Scott T Weiss, and Kathryn T Hall. 2019. “ Pharmacogenomics and Placebo Response in a Randomized Clinical Trial in Asthma .” Clin Pharmacol Ther, 106, 6, Pp. 1261-1267. Abstract Genetic variation may differentially modify drug and placebo treatment effects in randomized clinical trials. In asthma, although lung function and asthma control improvements are commonplace with placebo, pharmacogenomics of placebo vs. drug response remains unexamined. In a genomewide association study of subjective and objective outcomes...
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