Science > Genes

Charles Darwin's natural selection mystery solved after 160 years in stunning breakthrough

Charles Darwin's natural selection mystery solved after 160 years in stunning breakthrough

1 day ago   |   Daily Express

RESEARCHERS have cracked the code to Charles Darwin's pigeon enigma after they discovered a mutation in genes is linked to beak size reduction in pigeons.
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Promotion of somatic CAG repeat expansion by Fan1 knock-out in Huntington's disease knock-in mice is blocked by Mlh1 knock-out

3 days ago   |   Harvard   |   2 articles

Jacob M Loupe, Ricardo Mouro Pinto, Kyung-Hee Kim, Tammy Gillis, Jayalakshmi S Mysore, Marissa A Andrew, Marina Kovalenko, Ryan Murtha, IhnSik Seong, James F Gusella, Seung...
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Modifiers of Somatic Repeat Instability in Mouse Models of Friedreich Ataxia and the Fragile X-Related Disorders: Implications for the Mechanism of Somatic Expansion in Huntington's Disease

3 days ago   |   Harvard   |   3 articles

Xiaonan Zhao, Daman Kumari, Carson J Miller, Geum-Yi Kim, Bruce Hayward, Antonia G Vitalo, Ricardo Mouro Pinto, and Karen Usdin. 2021. “ Modifiers of Somatic Repeat Instability...
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Somatic CAG expansion in Huntington's disease is dependent on the MLH3 endonuclease domain, which can be excluded via splice redirection

3 days ago   |   Harvard   |   2 articles

Jennie CL Roy, Antonia Vitalo, Marissa A Andrew, Eduarda Mota-Silva, Marina Kovalenko, Zoe Burch, Anh M Nhu, Paula E Cohen, Ed Grabczyk, Vanessa C Wheeler, and Ricardo Mouro...
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Genetic Contributors to Intergenerational CAG Repeat Instability in Huntington's Disease Knock-In Mice

3 days ago   |   Harvard   |   3 articles

João Luís Neto, Jong-Min Lee, Ali Afridi, Tammy Gillis, Jolene R Guide, Stephani Dempsey, Brenda Lager, Isabel Alonso, Vanessa C Wheeler, and Ricardo Mouro Pinto. 2017. “...
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Heterozygous mutations cause genetic instability in a yeast model of cancer evolution

3 days ago   |   Harvard

Miguel C Coelho, Ricardo M Pinto, and Andrew W Murray. 2019. “ Heterozygous mutations cause genetic instability in a yeast model of cancer evolution .” Nature, 566, 7743, Pp...
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CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset

3 days ago   |   Harvard

2019. “ CAG Repeat Not Polyglutamine Length Determines Timing of Huntington's Disease Onset .” Cell, 178, 4, Pp. 887-900.e14. Abstract Variable, glutamine-encoding, CAA...
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Exploring Chromatin Dynamics in Human Brain Development and Disease

3 days ago   |   Harvard

Alfredo M. Valencia* and Sergiu P. Pasca. Forthcoming. “ Exploring Chromatin Dynamics in Human Brain Development and Disease .” Trends in Cell Biology...
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Science can rescue farming. Relaxing gene editing rules should be the start | Nick Talbot

4 days ago   |   The Guardian

As the UK prepares to approve genome editing, a leading food scientist argues it should also ease up on GM crops Empty shelves in supermarkets have reminded us that our food...
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A genetic screen to identify genes influencing the secondary redox couple NADPH/NADP+ in the yeast Saccharomyces cerevisiae

7 days ago   |   Harvard

Shambhu Yadav, Tejasvinee Atul Mody, Archi Sharma, and Anand Kumar Bachhawat. 2020. “ A genetic screen to identify genes influencing the secondary redox couple NADPH/NADP+ in...
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Listen: Scott Gottlieb on the next pandemic, another Covid winter, &...

What does Covid-19 have in store for this winter? Is Aduhelm a commercial dud? And are we prepared for the next pandemic? We cover all that and more this week on “The Readout... Read more ...

Disaster medicine training: The case for virtual reality

Derrick Tin, Attila J Hertelendy, and Gregory R Ciottone. 2021. “ Disaster medicine training: The case for virtual reality .” The American journal of emergency medicine, Pp... Read more ...

The case for an Australian disaster reserve force

Derrick Tin, Alexander Hart, and Gregory R Ciottone. 2020. “ The case for an Australian disaster reserve force .” American journal of emergency medicine. Publisher's Version Read more ...

Rise of the Unmanned Aerial Vehicles: An Imminent Public Health Threat...

Derrick Tin, Zachary Kallenborn, Alexander Hart, Attila J Hertelendy, and Gregory R Ciottone. 2021. “ Rise of the Unmanned Aerial Vehicles: An Imminent Public Health Threat... Read more ...

Tesla's 'Death Beam' brought to life - new invention can bring down PLANES

Tesla's 'Death Beam' brought to life - new invention can bring down PLANES

AN AUSTRALIAN inventor has become the first person in the world to build what twentieth-century inventor, Nikola Tesla, called a "Death Beam" or "Death Ray". Read more ...

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Microscopy

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NASA official says Starliner demo mission not likely to launch until next year

NASA official says Starliner demo mission not likely to launch until next year

Boeing's Starliner spacecraft returned to the Commercial Crew and Cargo Processing Facility at Kennedy Space Center on Aug. 19 for troubleshooting. Credit: Boeing The head of... Read more ...

Hardening hospital defences as a counter-terrorism medicine measure

Derrick Tin, Alexander Hart, Gregory R Ciottone, Daniel Chiang, Justine M Ade, Xiao-wei Liu, Christine M Lohse, Benjamin J Sandefur, Ronna L Campbell, and Katherine A Holmes... Read more ...

Rethinking disaster vulnerabilities

Derrick Tin, Alexander Hart, and Gregory R Ciottone. 2020. “ Rethinking disaster vulnerabilities .” American journal of emergency medicine. Publisher's Version Read more ...