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GenomegaMap within-species genome-wide dN/dS estimation from over 10,000 genomes

2 monthes ago   |   By Harvard

Daniel J Wilson and The CRyPTIC Conssortium. In Press. “ GenomegaMap within-species genome-wide dN/dS estimation from over 10,000 genomes .” Molecular Biology and Evolotion. Publisher's Version Abstract The d N / d S ratio provides evidence of adaptation or functional constraint in protein-coding genes by quantifying the relative excess or deficit of amino acid-replacing versus silent nucleotide variation. Inexpensive sequencing promises a better understanding of parameters such as d N / d S , but analysing very large datasets poses a major statistical challenge. Here I introduce...
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